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While some studies show mild benefits, overall evidence is inconsistent
The Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) tool was used to assess the certainty of the evidence for the two primary biochemical outcomesserum vitamin B12 concentration increase and homocysteine reductionacross all included studies, and separately for randomised controlled trials (RCTs) and observational studies
The components are supplied pre-blended at a fixed ratio and cannot be separated after manufacture
We do, however, see changes in UCK2 expression (Fig
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